IndiePlex HD exibe filmes independentes e documentários em todos os Estados Unidos, com foco em obras de diretores emergentes e pequenos estúdios de produção. A programação do canal prioriza longas narrativos, curtas-metragens e projetos de não ficção que frequentemente não chegam ao circuito comercial. O público pode esperar uma seleção rotativa de drama, comédia e cinema experimental, além de especiais ocasionais de música e documentários culturais. A grade evita intervalos comerciais durante as exibições de filmes, preservando a edição original de cada obra.

O acesso à transmissão online está disponível por meio de aplicativos de operadoras de TV selecionados e plataformas autenticadas de TV Everywhere. Os guias de programação listam os horários por fuso horário, com novos títulos adicionados a cada mês. O canal não produz conteúdo original nem realiza eventos ao vivo, selecionando sua programação a partir de aquisições em festivais e submissões diretas de cineastas.

Guia de TV
Goon: Last of the Enforcers
08:00 - 09:42
Goon: Last of the Enforcers
Movie, Comedy
A lockout has reunited old teammates and brought a crew of new players to the bench for the Halifax Highlanders. Sidelined after one too many hits and now married with a baby on the way, Doug "The Thug" Glatt hangs up his skates and settles into life as an insurance salesman. But when Doug's nemesis, Anders Cain, is made captain of the Highlanders and new ownership threatens to tear his team apart, Doug is compelled back into action.
Queen of Manhattan
09:42 - 11:22
Queen of Manhattan
Movie, Biography, Drama
The story of Vanessa Del Rio, set against the backdrop of organized crime-controlled Times Square during the 70's and 80's. Del Rio's career spans over 21 years and 200 films, making her a prolific early adult film entertainer and sex workers' rights proponent.
Art of Love
11:22 - 13:19
Art of Love
Movie, Romance, Drama
A professor at a top university in Puerto Rico falls in love with an aspiring artist from the immigrant Chinese community.
Prince of Central Park
13:19 - 15:13
Prince of Central Park
Movie, Drama
JJ chooses the streets of New York over his foster mother and must live by a new set of rules or risk becoming an NYPD statistic. Only one couple has a chance to save JJ, but a dark secret may stop them.
Goon: Last of the Enforcers
15:13 - 16:56
Goon: Last of the Enforcers
Movie, Comedy
A lockout has reunited old teammates and brought a crew of new players to the bench for the Halifax Highlanders. Sidelined after one too many hits and now married with a baby on the way, Doug "The Thug" Glatt hangs up his skates and settles into life as an insurance salesman. But when Doug's nemesis, Anders Cain, is made captain of the Highlanders and new ownership threatens to tear his team apart, Doug is compelled back into action.
Gutshot Straight
16:56 - 18:26
Gutshot Straight
Movie, Thriller, Crime drama
A debt-ridden gambler (George Eads) gets in over his head when a mysterious high-roller (Stephen Lang) hires him for a job that has an unexpected condition attached.
Strange Bedfellows
18:26 - 20:07
Strange Bedfellows
Movie, Comedy, LGBTQ
Vince Hopgood is a recently divorced theater owner with some serious tax problems. When Vince learns that a new tax loophole for live-in gay couples would allow him to keep his property, he asks his best friend, Ralph, to pose as his lover. In order to fool the taxman, the gruff, small-town Aussie pals make a clueless attempt to act like a homosexual couple. Along the way, they befriend actual gays and reevaluate stereotypes of the gay community.
The Rules of Attraction
20:07 - 21:58
The Rules of Attraction
Movie, Dark comedy, Drama, Romance
Based on the novel by Bret Easton Ellis, "Rules" centers around Patrick Bateman's younger brother and his college friends' bizarre mating rituals that mix sex, drugs, music and mayhem in a kaleidoscopic story about three students entangled in a curiously surreal romantic triangle...
Prince of Central Park
21:58 - 23:50
Prince of Central Park
Movie, Drama
JJ chooses the streets of New York over his foster mother and must live by a new set of rules or risk becoming an NYPD statistic. Only one couple has a chance to save JJ, but a dark secret may stop them.
Freezer
23:50 - 01:13
Freezer
Movie, Thriller, Action
A man (Dylan McDermott) fights for his life when Russian thugs lock him inside a freezer, accusing him of stealing millions of dollars.