HBO Comedy HD exibe uma seleção curada de filmes de comédia, especiais de stand-up e séries originais do acervo da HBO, apresentados em alta definição. O canal foca no humor em diversos subgêneros, incluindo comédias satíricas, românticas, dramáticas e programas de esquetes. Embora a programação seja rotativa, o conteúdo evita noticiários, esportes ou programação religiosa, concentrando-se no entretenimento baseado em comédia roteirizada e ao vivo. Como um canal doméstico nos Estados Unidos, atende principalmente assinantes que desejam um canal dedicado à comédia, sem os dramas ou documentários encontrados em outros canais da HBO.

Os telespectadores podem acessar o canal por meio de operadoras de TV a cabo e satélite participantes, geralmente como parte de um pacote premium. O mesmo conteúdo também está disponível sob demanda na plataforma de streaming HBO Max, onde episódios e filmes podem ser assistidos a qualquer momento. As listas de programação do canal linear são publicadas pelas operadoras locais e variam por região, com transmissão 24 horas por dia, sem intervalos comerciais.

Guia de TV
Tour de Pharmacy
07:48 - 08:28
Tour de Pharmacy
Special, Comedy
Five competitors provide an inside look at the world of professional cycling and its checkered history with doping.
Game Night
08:28 - 10:10
Game Night
Movie, Comedy, Action
Max and Annie's weekly game night gets kicked up a notch when Max's brother Brooks arranges a murder mystery party -- complete with fake thugs and federal agents. So when Brooks gets kidnapped, it's all supposed to be part of the game. As the competitors set out to solve the case, they start to learn that neither the game nor Brooks are what they seem to be. The friends soon find themselves in over their heads as each twist leads to another unexpected turn over the course of one chaotic night.
Starter for 10
10:10 - 13:43
Starter for 10
Movie, Romance, Comedy drama
Brian Jackson (James McAvoy), a working-class youth from Essex, gets a chance to prove himself when he is accepted to respected Bristol University. As Brian navigates his way through his first year there, he finds romance with two pretty students (Alice Eve, Rebecca Hall) and tries out for a popular TV program called "University Challenge.".
Table 19
13:43 - 15:11
Table 19
Movie, Comedy drama
Ex-maid of honor Eloise - having been relieved of her duties after being unceremoniously dumped by the best man via text - decides to hold her head high and attend her oldest friend's wedding anyway. She finds herself seated at the random table in the back of the ballroom with a disparate group of strangers, most of whom should have known to just send regrets. As everyone's secrets are revealed, Eloise learns a thing or two from the denizens of Table 19.
Get Him to the Greek
15:11 - 17:01
Get Him to the Greek
Movie, Comedy
An ambitious executive at a record company, Aaron Green (Jonah Hill) gets what looks like an easy assignment: He must escort British rock legend Aldous Snow (Russell Brand) to L.A.'s Greek Theatre for the first stop on a lucrative comeback-concert tour. Snow, however, has different plans. Learning his true love is in California, the rocker vows to win her back before starting the tour, forcing Aaron to pull out all the stops to get Snow on stage in time.
Magic Mike's Last Dance
17:01 - 18:53
Magic Mike's Last Dance
Movie, Comedy drama, Romance
Mike Lane takes to the stage once again when a business deal that went bust leaves him broke and bartending in Florida. Hoping for one last hurrah, Mike heads to London with a wealthy socialite who lures him with an offer he can't refuse -- and an agenda all her own. With everything on the line, he soon finds himself trying to whip a hot new roster of talented dancers into shape.
Ramy Youssef: Feelings
18:53 - 19:50
Ramy Youssef: Feelings
Special, Comedy, Standup
Comic/actor Ramy Youssef offers his thoughts on a number of subjects, including the best day of the week to pray, his father's immigration story and connection to Donald Trump, and his complicated love for LeBron James.
Ramy Youssef: More Feelings
19:50 - 20:45
Ramy Youssef: More Feelings
Special, Standup, Comedy
Ramy Youssef returns to the stage to offer his unique reflections on a divided world, the unexpected perils of charitable giving, the 2024 presidential election, prayer, and a childhood book report that changed the course of his life.
Prancer: A Christmas Tale
20:45 - 22:31
Prancer: A Christmas Tale
Movie, Family, Holiday, Drama, Fantasy
Ten-year-old Gloria and her recently widowed grandfather Bud befriend a mysterious reindeer when the family gathers for Christmas. Bud comes to believe that Prancer may actually be magical, but Gloria fears his theory will send him straight to a retirement home. They try to keep the secret while figuring out why the reindeer has appeared, and longstanding rifts within the family are healed along the way.
One Battle After Another
22:31 - 01:13
One Battle After Another
Movie, Thriller, Comedy drama
Bob is a washed-up revolutionary who lives in a state of stoned paranoia, surviving off-grid with his spirited and self-reliant daughter, Willa. When his evil nemesis resurfaces and Willa goes missing, the former radical scrambles to find her as both father and daughter battle the consequences of their pasts.