RetroPlex HD exibe filmes clássicos e séries de televisão de várias décadas da história do entretenimento americano. A programação do canal é baseada principalmente nos anos 1950 até os anos 1990, com foco em gêneros consagrados como ficção científica, faroeste, film noir e comédia. Telespectadores nos Estados Unidos podem esperar ver cortes teatrais originais de filmes antigos, além de episódios de TV de arquivo que foram ao ar originalmente em redes de transmissão. O conteúdo é apresentado em alta definição quando o material de origem permite, e intervalos comerciais estão incluídos como parte do sinal de transmissão linear.

Para quem prefere acesso sob demanda, o RetroPlex HD está disponível através de operadoras de TV a cabo e satélite selecionadas, bem como por certas plataformas de streaming que transmitem o sinal ao vivo do canal. As listagens de programação do canal são publicadas por distribuidoras locais e podem ser encontradas em guias eletrônicos de programação padrão. A grade de horários é renovada regularmente, com blocos temáticos aos finais de semana e feriados, embora nenhum título ou apresentador específico esteja vinculado

Guia de TV
Split Decisions
07:04 - 08:41
Split Decisions
Movie, Drama, Action
An Irish-American boxer (Craig Sheffer) turns pro with his father (Gene Hackman) for one fight, to avenge his slain boxer brother.
Crossworlds
08:41 - 10:13
Crossworlds
Movie, Science fiction, Comedy, Action
A magic crystal leads a college student (Josh Charles) and an adventurer (Rutger Hauer) on a surreal quest to save the world.
A Different Loyalty
10:13 - 11:59
A Different Loyalty
Movie, Drama
An expatriate (Sharon Stone) travels to the Soviet Union after her husband (Rupert Everett) is accused of being a double agent working for the KGB.
Iron Brothers
11:59 - 13:33
Iron Brothers
Movie, Action, Adventure
Fur trappers Abel and Henry Iron struggle to survive in the Rocky Mountains.
The Stranger
13:33 - 15:08
The Stranger
Movie, Thriller
Immediately following World War II, ex-Nazi Franz Kindler is living under a false identity as a teacher in a small Connecticut town, and has even married the headmaster's daughter as part of his cover. But when one of Kindler's old German associates arrives unexpectedly in town, bringing in his wake a sly federal investigator, Kindler resorts to desperate measures to preserve his secret.
Dust
15:08 - 17:13
Dust
Movie, Western, Drama
After falling in love with the same woman, two brothers (Joseph Fiennes, David Wenham) fight for opposing sides of a battle between Turks and Macedonians.
Beyond the Stars
17:13 - 18:46
Beyond the Stars
Movie, Drama
The son (Christian Slater) of a former NASA scientist (Robert Foxworth) befriends a fallen astronaut (Martin Sheen) changed for life by his moonwalk.
A Different Loyalty
18:46 - 20:32
A Different Loyalty
Movie, Drama
An expatriate (Sharon Stone) travels to the Soviet Union after her husband (Rupert Everett) is accused of being a double agent working for the KGB.
Crossworlds
20:32 - 22:04
Crossworlds
Movie, Science fiction, Comedy, Action
A magic crystal leads a college student (Josh Charles) and an adventurer (Rutger Hauer) on a surreal quest to save the world.
Split Decisions
22:04 - 23:41
Split Decisions
Movie, Drama, Action
An Irish-American boxer (Craig Sheffer) turns pro with his father (Gene Hackman) for one fight, to avenge his slain boxer brother.
Dust
23:41 - 01:46
Dust
Movie, Western, Drama
After falling in love with the same woman, two brothers (Joseph Fiennes, David Wenham) fight for opposing sides of a battle between Turks and Macedonians.